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(Senior) Scientist Investigative Toxicology

(Senior) Scientist Investigative Toxicology

  • Location

    San Francisco

  • Sector:

    Preclinical Development & Safety

  • Job type:

    Permanent

  • Salary:

    £0 per year

  • Contact:

    Jack Clay

  • Contact email:

    Jack.clay@catalystcareers.com

  • Contact phone:

    02035899300

  • Job ref:

    LM53086

  • Published:

    5 months ago

  • Expiry date:

    2020-05-05

Scientist - Investigative Toxicology

South San Francisco

My client is a clinical stage biotech dedicated to discovering the next generation of medicines for the treatment of serious diseases. The company has a well funded collaborative pipeline of seven drug candidates in various stages of development targeting metabolic diseases and cancer.

The role:

- Lead the Investigative Toxicology function to advance the mechanistic understanding of drug and target mediated toxicity

- Design and conduct experiments to help translate the nonclinical safety findings to humans

- Design, plan and execute in vitro and in vivo experiments to elucidate toxicity pathways; apply revolutionary technology to further our understanding of target organs and cell types for safety assessment

- Determine tissue expression of novel targets in nonclinical species utilizing various technologies

- Support R&D programs in the selection of appropriate nonclinical species for safety assessment

- Manage resources in the conduct of in-house and outsourced studies

Education:

- PhD degree (at least 2-5+ years' postdoctoral experience) in toxicology, pharmacology, molecular biology or another related discipline

Requirements:

- Proven experience with in vitro assay development and design of in vivo investigative toxicology studies

- Proven track record of solving complex biologic questions as they relate to mechanisms of drug induced pharmacology/toxicology

- Ability to immerse in the understanding of complex biologic pathways and identify key research activities of importance

- Proficiency in liver or cancer biology desirable

- Excellent communication and presentation skills to efficiently relay information to project teams and other key stakeholders

- Experience with large molecule drug discovery and development desired but not required

- Proven ability to work independently and be self-motivated